Senior Research Associate, CMC Process Sciences at Dyne Therapeutics, Apply Now!
Dyne Therapeutics is seeking a Senior Research Associate, CMC Process Sciences to play a crucial role in oligonucleotide conjugation process development. This hands-on laboratory position will contribute to process establishment, characterization, and validation to advance Dyne’s clinical assets. If you are passionate about bioconjugate drug development and thrive in a dynamic, collaborative environment, apply now!
Role Summary:
The candidate will be responsible for internal process development of oligonucleotide conjugates and provide technical support for validation activities. This laboratory-based position will involve hands-on contributions to process establishment, process development, process characterization, and validation. The Senior Research Associate will collaborate with other functions within Dyne including, but not limited to, analytical method development, quality control, and platform research. The candidate will participate directly in pre-clinical development as well as activities directly related to process validation of Dyne’s clinical assets. The candidate is expected to be passionate about conjugate drug development and working in a dynamic environment.
Primary Responsibilities Include:
- Responsible for drug substance process development, including bioconjugation chemistry, purification, and formulation.
- Lead internal CMC Process Development activities via hands-on contribution in the lab.
- Partner with Research to support bioconjugation development activities and enhance the tech transfer process to external manufacturing partners.
- Represent CMC and Process Sciences as a technical leader in internal cross-functional teams.
- Establish clear expectations and priorities, set objectives, and effectively apply resources to deliver on program goals.
- Contribute creative ideas and new innovations that enable better products and processes.
Education and Skills Requirements:
- A bachelor’s or master’s degree in biology, biochemistry, chemistry, or similar related life science or engineering field is required.
- A minimum of 3 years in Research & Development preferably in a clinical-stage biotechnology company.
- Experience working with bioconjugates including a deep understanding of conjugation chemistries, preparative chromatography, and TFF is required.
- Familiarity working with oligonucleotides including but not limited to antisense oligonucleotides, morpholino oligonucleotides, and siRNA is desired.
- Hands on experience with analytical techniques for characterization of conjugates including HPLC/UPLC, SEC, SDS-PAGE, ion exchange chromatography, and UV/vis.
- Ability to challenge current processes, practices, and strategy to uncover alternative approaches, solutions, or methods.
- Self-directed individual who is able to work effectively with limited direction in a complex, fast-paced environment.
Keywords: Senior Research Associate, CMC Process Sciences, Dyne Therapeutics, biotechnology, oligonucleotide conjugates, drug development, bioconjugates, Research & Development, chromatography, analytical techniques.
