Amgen Postdoctoral Fellow Job They are looking for dedicated, self-motivated individuals passionate about science and making high impact discoveries to work on Emerging Therapeutic Modalities. A major focus will be in the exciting area of Proximity Biology, including Targeted Protein Degradation, E3 ubiquitin ligases, PROTACs and molecular glues. Design principles to overcome challenges in Targeting, Develop-ability and ADME will be elucidated for these novel modalities. New postdoctoral fellows will take a multi-disciplinary approach combining chemical biology, molecular biology, biochemistry, cell biology, pharmacology, and analytical chemistry to carry out these studies.
Basic qualifications
PhD at the time of appointment
Preferred Qualifications
- PhD in biochemistry, molecular biology, cell biology, cancer biology, pharmacology, chemistry, or pharmaceutical sciences.
- Broad knowledge of molecular and cellular biology with demonstrated independent research eminence through first author publications in top journals
- Specific expertise and a record of publication in the biology and biochemistry of ubiquitin-proteasome system and/or protein degradation
- Research experience with biochemical, biophysical, molecular and cellular techniques, including enzyme and cell assay development, characterization of protein modification and turnover, and mechanistic studies of enzymes, including developing drug-target engagement assays
- Understanding of mechanistic pharmacokinetic principles including drug absorption, permeability, and key factors in optimizing bioavailability of new chemical entities
- Research experience with establishing novel assays to understand the role of drug transporters in both absorption and clearance
- Comprehensive knowledge of analytical chemistry with a focus on mass spectroscopy skills for quantitation of proteins and peptides out of biological matricesical matrices
- Excellent organizational, interpersonal and communication skills
- A passion to explore the unknown and make discoveries that will chart new areas of biology
Please see representative publications:
- Cell. 2015 160, 715-28.
- Cell. 152, 1051-1064.
- Molecular Cell. S1097-2765(20)30466-4.
- Molecular Cell. 77(6):1206-1221.e7.
- Molecular Cell. 69,113-25.
- Science Advances. 5(5):eaav4832.
- Nature Communications. 11(1):4931
- Drug Metab Dispos. DMD-AR-2021-000798
- Drug Metab Dispos. 47(10):1097-1099
- J Med Chem. 63(12):6407-6422
- Analytical Chemistry 93(13):5562-5569
Amgen Postdoctoral Fellow Job, Amgen Postdoctoral Fellow Job
