Two PhD Funded Positions Two PhD Funded Positions in Biochemistry “Using Enzymes to Make Macrocycles” at University of Graz in Austria
PhD Position (1) in the group of Biocatalytic Synthesis: A PhD position (focus on the synthetic application of enzymes), is available at the Institute of Chemistry at the University of Graz, Austria in the Group of Biocatalytic Synthesis under the supervision of Dr. Christoph Winkler.
The project is financed by the Austrian Science Fund and will be realized together with the Computer-Aided Molecular Design Lab at the Medical University of Graz. The objective is the development of an efficient enzymatic synthesis of challenging macrocycles. Two PhD students will work together on the topic, each focusing on different aspects. The position is for 3 years and ideally starts by January 2024.
► Our Offer
- 3-year PhD position at the University of Graz (gross: 2460,-/month x14, net: ~1800,-/month x 14)
- An exciting project in a diverse and collaborative environment in an internationally established working group (Group of Biocatalytic Synthesis; the lab of Prof. Wolfgang Kroutil, University of Graz)
- You will be trained in innovative techniques ranging from biocatalysis, organic synthesis and bioinformatics, to molecular biology and analytical methods
- You will gain experience in applying modern high throughput methodologies and enzyme engineering
► Your Profile
- Master’s degree or equivalent qualification in organic chemistry, biochemistry or a related discipline
- Eligible as a graduate student at University of Graz (Austria)
- Experience and sound knowledge in organic synthesis, biotransformations and enzyme expression
- Any additional experience in one or more of the following topics is beneficial: molecular biology, analytical methods (HPLC, GC, NMR) or bioinformatics (e.g., Pymol, Yasara, BLAST)
- Excellent spoken and written English
- The ability to work both independently and as part of an international research team
► Your Tasks
- Synthesis of new substrates and reference compounds; development of analytical methods
- Cloning, expression and characterization of new biocatalysts
- Design of enzymatic cascades by combining multiple biocatalysts in one pot
- Upscaling and application of novel biocatalytic systems to produce pharmaceutic target compounds
How To Apply:
► Interested? Send your application consisting of a cover letter, CV, letter of motivation and your MSc certificate (or equivalent) electronically to [email protected] no later than October 31, 2023 with “P37113-PhD1” as subject.
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PhD Position (2) in the group of Biocatalytic Synthesis :
A PhD position (focus on molecular and structural biology) is available at the Institute of Chemistry at the University of Graz, Austria in the Group of Biocatalytic Synthesis under the supervision of Dr. Christoph Winkler, together with Ass.-Prof. Dr. Pedro Alejandro Sánchez Murcia from Computer-Aided Molecular Design Lab at the Medical University of Graz.
The objective is the development of an efficient enzymatic synthesis of challenging macrocycles. Two PhD students will work together on the topic, each focusing on different aspects. The position is for 3 years and ideally starts by January 2024.
Their Offer
- 3-year PhD position at the University of Graz (gross: 2460,-/month x14, net: ~1800,-/month x 14)
- An exciting project in a diverse and collaborative environment in two different internationally established working groups: the Group of Biocatalytic Synthesis (the lab of Prof. Wolfgang Kroutil, University of Graz) and the Computer-Aided Molecular Design Lab (the lab of Ass.-Prof. Dr. Pedro Alejandro Sánchez Murcia, Medical University of Graz)
- You will be trained in innovative techniques ranging from biocatalysis and organic synthesis to molecular biology, with focus on computational chemistry methods and bioinformatics
- You will gain experience in applying modern high throughput methodologies and enzyme engineering
► Your Profile
- Master’s degree or equivalent qualification in organic chemistry, biochemistry or a related discipline
- Eligible as a graduate student at University of Graz (Austria)
- Experience and sound knowledge in molecular biology, biotransformations and bioinformatic
- ▪ Any additional experience in one or more of the following topics is beneficial: organic synthesis and analytics (HPLC, GC, NMR) or computational chemistry (MD and/or QM/MM MD simulations)
- Excellent spoken and written English
- The ability to work both independently and as part of an international research team
► Your Tasks
- Sequence based enzyme identification and establishment of sequence similarity networks
- Cloning, expression and characterization of new biocatalysts
- Computational modelling of enzyme-substrate interactions and enzymatic reaction mechanisms
- Molecular Docking, MD simulations and QM/MM MD simulations
How To Apply
► Interested? Send your application consisting of a cover letter, CV, letter of motivation and your MSc certificate (or equivalent) electronically to [email protected] no later than October 31, 2023 with “P37113-PhD2” as subject.
Two PhD Funded Positions
