CRISPR Therapeutics Life Science Job Opening 2020
Research Associate II to join an exciting, fast-growing and well-financed company to develop novel gene editing therapies for serious diseases. The successful candidate will join the Technical Operations (Tech Ops) group at CRISPR Therapeutics, focusing on the development of analytical methods for ex vivo genetically modified cells to support the development of gene editing programs.
Job Title: Research Associate II, Analytical Development
Location Cambridge, MA, US
Position Summary
CRISPR Therapeutics Life Science They are seeking a Research Associate II to join an exciting, fast-growing and well-financed company to develop novel gene editing therapies for serious diseases. The successful candidate will join the Technical Operations (Tech Ops) group at CRISPR Therapeutics, focusing on the development of analytical methods for ex vivo genetically modified cells to support the development of gene editing programs. The individual will develop quantitative assays measuring gene editing in target and non-target cells, cell-based assays measuring the expression and the biological functions of specific genes. The successful candidate will independently design, perform, and analyze experiments for multiple preclinical and clinical programs, and will work independently to support process development, product characterization, and technical transfer to CMOs and GMP test labs.
Responsibilities
- Develop cell-based assays measuring gene expression/function, and virus infectious titer
- Develop and qualify quantitative assays measuring process impurities
Work with Process Development to generate and analyze process development data to develop an understanding of cellular product critical quality attributes to guide testing and process control strategies - CRISPR Therapeutics Life Science Develop and maintain T-cell banks used for cell-based potency assays
- Develop and qualify quantitative assays used to measure consistency across donor samples
- Work with Process Development to generate and analyze process development data to develop an understanding of cellular product critical product parameters to guide testing and process control strategies
- Develop data sets supporting product specification and for qualification and/or validation of cell-based assays at CMOs and GMP test labs
- CRISPR Therapeutics Life Science Author technical reports on assay development/optimization and SOPs for assay performance
- Analyze and present experimental data
- Assess and implement new analytical technologies
Minimum Qualifications
CRISPR Therapeutics Life Science
- BS in life sciences and 2+ years of relevant assay development experience in industry or an MS.
- Experience with cell culture and flow cytometry is required
- Hands-on experience in development of cell banks is desired
- Experience in analytical method development, qualification/validation is preferred
- Hands-on experience in the development of cell-based assays
- Excellent oral and written communication skills
Preferred Qualifications
CRISPR Therapeutics Life Science
- Experience with assay development for immunology or immuno-oncology products
- Experience in assay development for cell and gene therapy products
- Experience in development of cell-based potency assays
- Experience working with primary cells
- Experience in tech transfer of assays to QC labs
- Understanding of assay development and qualification per regulatory guidance (USP, ICH)
Competencies
CRISPR Therapeutics Life Science
Collaborative – Openness, One Team
Undaunted – Fearless, Can-do attitude
Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
Entrepreneurial Spirit – Proactive. Ownership mindset.
