Scientist I at Wyss Institute at Harvard University, Apply Now!
The Wyss Institute at Harvard University is seeking a Scientist I to join its cutting-edge Brain Targeting Program. This full-time role offers an exciting opportunity to contribute to the development of brain delivery technologies that aim to revolutionize treatments for brain diseases. As part of a collaborative team, you’ll work on identifying and validating novel shuttle targets that improve drug transport across the blood-brain barrier (BBB).
Job Posting: Scientist I at Wyss Institute at Harvard University
Req ID: 68159BR
About the Role:
The Wyss Institute’s Brain Targeting Program (BTP) is developing brain delivery technologies that enable the development of safer and more effective brain-targeted therapeutics. We are looking for a talented Scientist to support the development of our novel brain shuttle target identification and validation platform.
What you’ll do:
- Execute on assigned projects in the development and optimization of the brain shuttle target identification and validation.
- Perform and optimize sample preparation for proteomics, including cell type isolation, tissue homogenization, digestion, and enrichment, and coordinate with internal or external mass spectrometry facilities.
- Design and execute protein expression validation assays, including Western blotting, ELISA, immunohistochemistry, and FACS, adapting protocols as needed for novel targets and reagents. Support and help execute in vitro and in vivo assays using antibodies, peptides, or other ligands to evaluate the transport potential of selected targets. Design and troubleshoot experiments, drawing from emerging literature and incorporating new approaches into assay development and experimental approaches.
- Participate in the analysis of multi-omics datasets (RNA-seq and proteomics) to help prioritize target proteins for further validation based on expression profiles and predicted function.
- Mentor and and train less experienced team members or academic interns as needed. May supervise technicians.
- Present experimental results and project updates at internal meetings and contribute to recommending next steps for experiments. Take an active role in strategy discussions related to these experiments.
- Demonstrate a commitment to teamwork, scientific rigor, and collaboration within and across teams
Basic Qualifications
What you’ll need:
- Bachelor’s degree in neuroscience, biology, molecular biology, biochemistry, or related field.
- Minimum of four years of hands-on experience in relevant techniques.
Additional Qualifications and Skills
Desirable skills:
- A PhD in neuroscience, biology, molecular biology, biochemistry or a related field is strongly preferred.
- Experience with RNA-Seq and proteomics datasets, microvessel isolation, cell type isolation, and biotinylation, is helpful but not required.
- Experience with sample preparation for proteomic analysis.
- Experience with antibody/peptide/AAV transport assays. Ability to work well independently and to collaborate with a multidisciplinary group.
- Proficiency with personal computers and applicable software packages (Microsoft Office, R, Prism, flowJo, and others).
Benefits
- Paid Time Off: 3-4 weeks of accrued vacation time per year (3 weeks for support staff and 4 weeks for administrative/professional staff), 12 accrued sick days per year, 12.5 holidays plus a Winter Recess in December/January, 3 personal days per year (prorated based on date of hire), and up to 12 weeks of paid leave for new parents who are primary care givers.
- Health and Welfare: Comprehensive medical, dental, and vision benefits, disability and life insurance programs, along with voluntary benefits. Most coverage begins as of your start date.
- Work/Life and Wellness: Child and elder/adult care resources including on campus childcare centers, Employee Assistance Program, and wellness programs related to stress management, nutrition, meditation, and more.
- Retirement: University-funded retirement plan with contributions from 5% to 15% of eligible compensation, based on age and earnings with full vesting after 3 years of service.
- Tuition Assistance Program: Competitive program including $40 per class at the Harvard Extension School and reduced tuition through other participating Harvard graduate schools.
- Tuition Reimbursement: Program that provides 75% to 90% reimbursement up to $5,250 per calendar year for eligible courses taken at other accredited institutions.
- Professional Development: Programs and classes at little or no cost, including through the Harvard Center for Workplace Development and LinkedIn Learning.
- Commuting and Transportation: Various commuter options handled through the Parking Office, including discounted parking, half-priced public transportation passes and pre-tax transit passes, biking benefits, and more.
- Harvard Facilities Access, Discounts and Perks: Access to Harvard athletic and fitness facilities, libraries, campus events, credit union, and more, as well as discounts to various types of services (legal, financial, etc.) and cultural and leisure activities throughout metro-Boston.
Keywords: Scientist I, Wyss Institute, Harvard University, research, healthcare, sustainability, brain drug delivery
